Preliminary Study on Extracting Technique and Biological Activity of Fucoidin in Undaria Pinnatifida
To investigate extracting technique and potential biological activity of fucoidin in Undaria pinnatifid, a kind of marine organisms. Factors such as solid-liquid ratio (times), time of extraction (min) and temperature of extraction (℃) were chosen to be investigated to examine the best extracting technique. 50 mice were randomed to negative comparison group, positive comparison group and experiment groups. Mice were inoculated tumor stock S180. The negative comparison group were administrated with physiological saline, positive comparison group administrated with astragalus polyose(50mg/(kgd)), and experiment groups administrated with fucoidin(100mg/(kgd), 50mg/(kgd), 25mg/(kgd)). The tumors were peeled and weighted after 7 days. The best extracting condition is definite to be 100 ℃, 60 times of water and 7h. The content of fucoidin in Undaria pinnatifida is 55.4％ after preliminary purification. The tumor inhibition rate of experiment groups are 56.19％, 65.71％ and 30.48％. The results of investigation on orthogonal experiments are reliable. And fucoidin in Undaria pinnatifida has certain antitumor effect.
JI Yubin YANG Bo
Center on life sciences and environmental sciences, Harbin, 150076,China Engineering research center School of pharmacy.Harbin University of Commerce, Harbin,150076,China Center on life sciences and en
国际会议
哈尔滨
英文
887-890
2011-03-26（万方平台首次上网日期，不代表论文的发表时间）