Analysis of single nanoparticle detection by using 3-dimensionally confined optofluidic ring resonators
Viral particles are responsible for the majority of human fatal diseases, including Ebola fever, influenza, HIV, SARS, dengue fever, and so on. Those small infectious agents with radius ranging from 1 nm to 800 nm spread and transmit extremely rapidly, and leave very limited time for treatment if humans are infected 1. The prevention and early diagnosis of those diseases require fast and trace amount detection of virus in liquid and in air. Among many approaches employed, the optical ring resonator based biosensor is one of the most sensitive devices, capable of detecting a single virion or nanoparticle in a real-time and label-free manner 2-3. In a ring resonator, light circulates and forms whispering-gallery modes (WGMs). When a virion or nanoparticle binds onto the resonator surface, its interaction with the WGM leads to a spectral shift or mode splitting 2-3. To date, by measuring the wavelength shift, a single influenza particle (50 nm in radius) in liquid has been detected experimentally with a solid microsphere 2. Recently, by measuring the mode splitting, the detection and sizing of a single nanoparticle (30 nm in radius) in air have also been demonstrated with a microtoroid 3. However, despite their excellent sensing performance, both structures lack of an efficient fluidic system to rapidly deliver samples to the sensing head (I.e., the ring resonator), which may significantly lengthen the detection time, in particular, when detecting a single nanoparticle.sensitive devices, capable of detecting a single virion or nanoparticle in a real-time and label-free manner 2-3.
Hao Li Yunbo Guo Yuze Sun Karthik Reddy Xudong Fan
Department of Biomedical Engineering, University of Michigan, 1101 Beal Ave., Ann Arbor, MI 48109 Ke Department of Biomedical Engineering, University of Michigan, 1101 Beal Ave., Ann Arbor, MI 48109
国际会议
Asia Communications and Photonics Conference and Exhibition(2010亚洲光纤通信与光弹博览会及研讨会 ACP 2010)
上海
英文
324-325
2010-12-08（万方平台首次上网日期，不代表论文的发表时间）