Selective Enrichment of Biomolecules Containing Cis-diols Using Boronic acid-modifed Gold Nanoparticles for Capillary Electrophoresis Analysis

摘要：

In this study, a selective enrichment method is developed for fast and efficient biomolecules containing cis-diols investigation. Gold nanoparticles were first synthesised ,then modifed with 4-mercaptophenylboronic acid to provide porous substrate with large specific surface and dual functions. Catechol was employed as a standard biomolecules to investigate the enrichment efficiency. In this way, the enrichment, washing and detection steps can all be investigated. Under the optimized conditions, the sensitivity was enhanced by 20-fold as compared with regular CE. With the established method, catechol in a human urine sample was determined.

作者: Zhuxing Tang Qiaoling Wang Chunhui Deng Xiangmin Zhang

作者单位: School of Environmental and Chemical Engineering, Shenyang Ligong University, Shenyang 110159, China Shenyang Medical College, Shenyang 110034, China Department of Chemistry, Fudan University, Shanghai 200433, China

会议类型: 国际会议

会议名称: The 6th International Conference on Physical and Numerical Simulation of Materials Processing(第六届材料与热加工物理模拟及数值模拟国际学术会议 ICPNS 2010)

会议地点: 桂林

会议语种:英文

页码: 1-6

在线出版日期: 2010-11-16（万方平台首次上网日期，不代表论文的发表时间）