Development and validation of an efficient lc-ms method for the simultaneous quantifictaion of ephedrines in urine
Introduction: Ephedrine (EP) , pseudoephedrine (PEP) , norephedrine (NEP) , methylephedrine (MEP) and norpseudoephedrine (NPEP) (Fig. 1) are five stimulants usually abused by athletes. According to WADA (World Anti-Doping Agency) regulations, NEP is not on the prohibited list and can be used unrestricted. For NPEP a threshold of 5μg/ml, EP and MEP a threshold of 10μg/ml and PEP a threshold of 150μg/ml is employed. The aim of this work is to develop and validate a quantitative method for direct urinary detection of ephedrines by LC coupled to single quadrupole MS. The applicability of the developed method is tested by analyzing spiked samples as well as educational samples obtained from World Association of Anti-Doping Scientists (WAADS).
Ying Dong Xiaobing Wang Shan Wang Jianghai Lu Kuan Yan Youxuan Xu
China Anti-Doping Agency, Beijing, China
国际会议
The 16th Asian Games Science Congress(第16届亚洲运动会科学大会)
广州
英文
421-422
2010-10-10（万方平台首次上网日期，不代表论文的发表时间）