Pharmacophore Mapping and Virtual Screening Based on the Cochicine Binding Site for Hit Identification

摘要：

Pharmacophores have been widespread use in medicinal chemistry for hit and lead identification and during the subsequent lead optimization. The most important consideration is to find novel chemotype hits that provide us a new direction for a project to explore. By using the software Discovery Studio 2.5, we tried to build a pharmacophore model based on the cochicine binding site.

作者: Xiao-feng Wang Bing-jie Qin Lan Xie

作者单位: Beijing Institute of Pharmacology & Toxicology, 27 Tai-ping Road, Beijing, 100850

会议类型: 国际会议

会议名称: The 5th International Conference of Molecular Simulations and Applied Informatics Technologies(第五届国际分子模拟与信息技术应用学术会议 ICMS&I)

会议地点: 武汉

会议语种:英文

页码: 177-178

在线出版日期: 2010-09-01（万方平台首次上网日期，不代表论文的发表时间）