Current Strategies for the Discovery of K+ Channel Modulators
Potassium ion (K+) channels consist of a ubiquitous family of membrane proteins that play critical roles in a wide variety of physiological processes, such as the regulation of neuronal excitability, muscle contraction, cell proliferation, and insulin secretion. Due to their pivotal functions in biological systems, K+channels have long been attractive targets for the rational drug design on the basis of their structures and interaction mechanisms. Various small-molecular compounds and toxins have been discovered to act as K+channel modulators. In the present review, we will first briefly discuss current knowledge of the structures and functions of K+channels, and then review the recent strategies for the discovery of K+channel modulators, focusing especially on the virtual screening approaches and chemical synthesis technologies.
Deju Ye Jiang Wang Kunqian Yu Yu Zhou Hualiang Jiang Kaixian Chen Hong Liu
The Center for Drug Discovery and Design, State Key Laboratory of Drug Research, Shanghai Institute The Center for Drug Discovery and Design, State Key Laboratory of Drug Research, Shanghai Institute
国际会议
武汉
英文
628-641
2010-09-01（万方平台首次上网日期，不代表论文的发表时间）