Discovering novel quercetin-3-O-amino acid-esters as a new class of Src tyrosine kinase inhibitors

摘要：

Quercetin-3-O-amino acid-esters, a new type of quercetin derivatives, were successfully prepared for the first time. Different from quercetin, the novel compounds show higher selectivity as inhibitors against Src tyrosine kinase (IC50 values ranging from 3.2 μM to 9.9 μM) than against EGFR tyrosine kinase. Molecular docking reveals that both hydrophobic and hydrogen bonding interactions are important to the selectivity. Therefore, this study provides a new promising scaffold for further development of new anticancer drugs targeting Src tyrosine kinase.

作者: He Huang Hualiang Jiang Hong Liu Qi Jia Jingui Ma Guangrong Qin Yingyi Chen Yonghua Xi Liping Lin Weiliang Zhu Jian Ding

作者单位: Shanghai Institute of Materia Medico, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201 School of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 201203, China

会议类型: 国际会议

会议名称: The 5th International Conference of Molecular Simulations and Applied Informatics Technologies(第五届国际分子模拟与信息技术应用学术会议 ICMS&I)

会议地点: 武汉

会议语种:英文

页码: 711-717

在线出版日期: 2010-09-01（万方平台首次上网日期，不代表论文的发表时间）