Steeper Action Potential Duration Restitution Slope Increases Risk of Ventricular Fibrillation:A Simulation Study

摘要：

Action potential duration restitution(APDR) is thought to be relevant to the stability of cardiac electrophysiology. Ventricular fibrillation (VF) was simulated using the Wei-Harumi model by taking into account piecewise linear action potential duration restitution based on clinical findings. We found, in the simulation, that heart model with steeper slope of APDR required less ectopic stimuli to trigger VF. This result suggested that the APDR may affect cardiac vulnerability to VF.

作者: Yi Zheng Daming Wei Zuxiang Fang

作者单位: Dept.of Electronic Engineering, Fudan University, Shanghai, People’s Republic of China Graduate Scho Graduate School of Computer Science and Engineering, University of Aizu, Aizu-Wakamatsu, Fukushima 9 Dept.of Electronic Engineering, Fudan University, Shanghai, People’s Republic of China

会议类型: 国际会议

会议名称: The 4th International Conference on Bioinformatics and Biomedical Engineering(第四届IEEE生物信息与生物医学工程国际会议 iCBBE 2010)

会议地点: 成都

会议语种:英文

页码: 1-4

在线出版日期: 2010-06-18（万方平台首次上网日期，不代表论文的发表时间）