A New Method for Identification Potential SNP Relating to Trait on Highly Polymorphic Gene Sequence Combination NCBI database and Multisequence Alignment software

摘要：

The traditional methods for identification potential SNP related to trait on highly polymorphic gene sequence needs complex SNP statistic and analytical procedure with the premise that positive data and negative data all fulfill, but sometime we only get a small quantity sequence data of positive trait individuals for time, difficulty or other causes and may be unable to get complete negative trait individual sample data in time, can we speculate potential SNP loci beforehand? This paper shows us new method to solve this problem in the genetic epidemic disease research of psoriasis vulgaris by combination the SNP database in NCBI and multi-sequence alignment. Through the application of this method to the analysis of positive sequence of HLA-C genes, found 31 potential SNP loci that NCBI records relates to the disease in total.

作者: Hongbin Lee Bo Wang

作者单位: school of life science and technology xian jiaotong university Xian, China

会议类型: 国际会议

会议名称: The 4th International Conference on Bioinformatics and Biomedical Engineering(第四届IEEE生物信息与生物医学工程国际会议 iCBBE 2010)

会议地点: 成都

会议语种:英文

页码: 1-4

在线出版日期: 2010-06-18（万方平台首次上网日期，不代表论文的发表时间）