Surface-Modification Superparamagnetic Nanoparticles for Highly-Efficient Intracellular Hyperthermia

摘要：

Functionalized superparamagnetic iron oxide nanoparticles (SPIONs) can play crucial roles for medical applications such as cancer magnetic induction hyperthermia, magnetic resonance imaging and magnetofection. Herein we report the results of modified magnetic nanoparticles coated with protamine peptides containing nuclear localization signal sequences. Functionalization of these SPIONs under alternating magnetic field radiation resulted in more cellular uptake and higher-efficient cytotoxicity in HepG2 cells. The work demonstrates that functionalized SPIONs can be used as a novel kind of highly efficient magnetic mediator for magnetic induction intracellular hyperthermia.

作者: Xiaowen Wang Sixing Kan Lingyun Zhao Jintian Tang Benke Chen

作者单位: Key Laboratory of Particle & Radiation Imaging,Tsinghua University, Ministry of Education Beijing, C Department of Biological Pharmaceuticals, Beijing University of Chinese Medicine Beijing, China

会议类型: 国际会议

会议名称: The 4th International Conference on Bioinformatics and Biomedical Engineering(第四届IEEE生物信息与生物医学工程国际会议 iCBBE 2010)

会议地点: 成都

会议语种:英文

页码: 1-5

在线出版日期: 2010-06-18（万方平台首次上网日期，不代表论文的发表时间）