Evolutionary implications of protein domain network in eukaryotes

摘要：

Complex network theory is utilized to explore the implication of protein domain content on evolution of eukaryotes. Comparative analysis of domains and their combination networks of eukaryotic organisms ranging over different phylogenetic groups demonstrate that: (1) topological features of domain combination network are correlated with organismal complexity; (2) globally central domains, defined by k-core decomposition method, are more structurally flexible than peripheral ones in terms of statistical e-value scores. We hypothesize that it might be flexibility under nature selection to make promiscuous domains more capable to incorporate other domains in order to achieve functional complexity in higher organisms.

作者: Chen Cao Xueying Xie Zuhong Lu

作者单位: School of Biological Science and Medical Engineering, Southeast University, Nanjing, China, 210096 Research Center for Learning Science, Southeast University, Nanjing, China, 210096 School of Biological Science and Medical Engineering, Southeast University, Nanjing, China, 210096 R

会议类型: 国际会议

会议名称: The 4th International Conference on Bioinformatics and Biomedical Engineering(第四届IEEE生物信息与生物医学工程国际会议 iCBBE 2010)

会议地点: 成都

会议语种:英文

页码: 1-4

在线出版日期: 2010-06-18（万方平台首次上网日期，不代表论文的发表时间）