Chicken Polymorphism at Pre-MicroRNAs Inferred from SNP Data
In this study, the SNPs located in the chicken premicroRNAs were performed a genome-wide analysis. The result showed that pre-microRNA SNPs are negatively selected in respect to SNPs distribution between the pre-microRNA and their flanking regions. Interestingly, the seed regions show a higher SNP density than both the MIR and the other MIR regions excluding seed regions. Furthermore, the SNPs in the seed regions were found show fewer effects on the stability of the pre-microRNA secondary structure. The data suggest that there is a rapid evolution has occurred in the seed regions and these SNPs are tend to be more deleterious , being good candidates for causal phenotypic variability among chickens. These findings will improve our understanding of the functions, evolution of chicken pre-microRNAs.
Chuan-sheng Zhang Li-ying Geng Jin Zhang Wen-jin Zhu Li-xin Du
Department of Animal Science Hebei Normal University of Science&Technology, HNUST,Qinhuangdao, China National Center for Molecular and Breeding of Animal,Institute of Animal Science, Chinese Academy of
国际会议
成都
英文
1-4
2010-06-18（万方平台首次上网日期，不代表论文的发表时间）