Characterization of Codon Usage Bias in the Newly Identified DEV UL53 Gene
Codon usage bias in UL53 gene of DEV was analyzed in this paper, the results indicated that it had strong bias towards to the synonymous codons with A or T at the third codon position. The codon usage bias of DEV UL53 gene and 26 reference herpesviruses were analyzed by EMBOSS program and RSCU. In addition, Phylogenetic tree indicated DEV was evolutionarily closer to CaHV-2, CaHV-3, MeHV-1. The ENC-GC3S plot revealed that the genetic heterogeneity in UL53 gene of herpesviruses was constrained by G+C content at the third codon position. Conclusions ：The extent of codon usage bias in the DEV UL53 gene was highly correlated with the gene composition. Analysis of correspondence through the SAS statistics software showed the yeast expression system might be more suitable for the expression of DEV genes.
Shunchuan Zhang Anchun Cheng Mingshu Wang Anchun Cheng Mingshu Wang
Avian Disease Research Center College of Veterinary Medicine of Sichuan Agricultural University Ya’a Key Laboratory of Animal Disease and Human Health ofSichuan Province College of Veterinary Medicine Key Laboratory of Animal Disease and Human Health of Sichuan Province College of Veterinary Medicine
国际会议
成都
英文
1-9
2010-06-18（万方平台首次上网日期，不代表论文的发表时间）