Fluctuation resonance of different genetic feed forward loops

摘要：

The feed forward loop (FFL) is one of the most important “network motifs in gene networks. Here we have numerically studied the response of eight genetic FFLs to external oscillatory signals. We find that, for the first gene X, the pure fluctuation resonance (FR) occurs at 2ω0. For the second gene Y, the FR curves have some, but little difference between the positive and negative regulation types of Y by X. The FR curves of the third gene Z have different cases according to the FFL types, coherent or incoherent, with single peak of low frequency in coherent types or double peaks of low and medium frequency in incoherent types. The results show that the FFL types have much effect on the signal transduction of gene networks.

作者: Zhiwei Wang

作者单位: Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin University of Science and Technology, Tianjin, China 300457

会议类型: 国际会议

会议名称: The 4th International Conference on Bioinformatics and Biomedical Engineering(第四届IEEE生物信息与生物医学工程国际会议 iCBBE 2010)

会议地点: 成都

会议语种:英文

页码: 1-4

在线出版日期: 2010-06-18（万方平台首次上网日期，不代表论文的发表时间）