Apop-1 Induces caspase-dependent Apoptosis

摘要：

Apoptosis is a form of genetically programmed cell death, which plays a pivotal role in normal development and the maintenance of homeostasis of a variety of tissues including cardiovascular system. Apop-1 is a soluble protein consisting of 194 amino acids with a mitochondrial localization signal at its N-terminus. RT-PCR data revealed that Apop-1 is expressed in all the organs tested. Immunofluorescence study showed that Apop-1 protein is localized in mitochondria. Transient transfection experiment showed Apop-1 induces apoptosis of cultured VSMC, and this apoptosis is inhibited by a pan-caspase inhibitor Z-VAD. The apoptosis induced by Apop-1 may contribute to the loss of VSMC in atherosclerosis, which will influence the stability of atherosclerotic plaques.

作者: Xin Sun Gang Lv Ling Gao Fanli Kong Xiaotao Zhu Dan Tian Haibin Tong Xiaodan Chu Yu Xie

作者单位: Life Science Center, Beihua University China Department of Surgery, Central Hospital of Jilin, Jilin, China

会议类型: 国际会议

会议名称: The 4th International Conference on Bioinformatics and Biomedical Engineering(第四届IEEE生物信息与生物医学工程国际会议 iCBBE 2010)

会议地点: 成都

会议语种:英文

页码: 1-4

在线出版日期: 2010-06-18（万方平台首次上网日期，不代表论文的发表时间）