Effect of oxygen level on efficiencies of metabolic fluxes in Klebsiella pneumoniae

摘要：

Control-effective flux(CEF) analysis is a useful tool in assessing a metabolism. In this work, a model that utilizes existing knowledge of oxygen and redox sensing/regulatory system to assist elementary flux modes (EFMs), has been developed and CEF analysis was performed to analyze the influence of oxygen level on the transcriptional regulation in Klebsiella pneumoniae. It was found that the efficiency of reductive pathway was higher than oxidative pathway under anaerobic condition and reversed under aerobic condition. During the transition from anaerobic to aerobic conditions, the efficiencies of oxidative pathway in tricarboxylic acid and pentose phosphate pathway increased, and that the efficiencies of PDOR and other fermentative product pathway decreased.

作者: Qingrui Zhang Weiwen Wang Hua Xiao Zhilong Xiu

作者单位: College of Chemical Engineering,Qingdao University of Science and Technology,Qingdao 266042, PR Chin Department of Bioscience & Biotechnology, Dalian University of Technology Dalian 116023, PR China

会议类型: 国际会议

会议名称: The 4th International Conference on Bioinformatics and Biomedical Engineering(第四届IEEE生物信息与生物医学工程国际会议 iCBBE 2010)

会议地点: 成都

会议语种:英文

页码: 1-4

在线出版日期: 2010-06-18（万方平台首次上网日期，不代表论文的发表时间）