The exploration of mammalian mitochondrial genes through integrating multiple lines of genome-wide biological evidence
Mitochondria are a vital organelle of eukaryotic cells. Many diseases are caused by the mitochondrial gene mutation , therefore, there is an urgent requirement to explore the proteins of mitochondrion. In this paper we have created a list of 1086 human mitochondrial genes by combining 13 datasets from publications or genomic experiments. Then we created a functional linkage network among mitochondrial genes by integrating multiple lines of biological evidence, and utilized the network to predict the function of the mitochondrial genes, including identifying some novel components involved in the KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways and the MIPS complexes. Our results indicated that it is very useful to study mitochondrial biology and disease by integrated genomic and proteomic datasets.
Jiabao Xu Sunpeng Wang Zhongrui Yi Yizheng Zhang Xiao Li Quansheng Feng Xinjian Fan
College of Life Sciences Sichuan University Chengdu, People’s Republic of China Chengdu University of TCM Chengdu, People’s Republic of China Chengdu University of TCM Chengdu, People’s Republic of China
国际会议
成都
英文
1-4
2010-06-18（万方平台首次上网日期，不代表论文的发表时间）