Induction of cytochrome CYP4F3 in hydroquinone-treated HL-60 cells

摘要：

Cytochrome P450 4F3 (CYP4F3) catalyzes the inactivation of leukotriene B4 by ω-oxidation in human neutrophils. Here, we examined the mRNA and protein expression of the CYP4F3 in HL-60 cells, an acute promyelocytic leukemia cell line, in the presence of hydroquinone(HQ). We found hydroquinone led to a decrease in cell proliferation and a increase in cell apoptosis in a dose-dependent and time-dependent manner, it also most strongly induced the expression of the CYP4F3. CYP4F3 appears to be responsible for the cell proliferation and cell apoptosis, which may be play a role in the toxicity of hydroquinone.

作者: yuhong Li hong Wang jing Hu zhongling ZHu zhiwei ZHao yongyi Bi

作者单位: School of Public Health,Wuhan University,Wuhan, Hubei 430071, China School of Medicine,Wuhan Univers School of Public Health,Wuhan University,Wuhan, Hubei 430071, China School of Public Health, Wuhan University, Wuhan, Hubei 430071, China

会议类型: 国际会议

会议名称: The 4th International Conference on Bioinformatics and Biomedical Engineering(第四届IEEE生物信息与生物医学工程国际会议 iCBBE 2010)

会议地点: 成都

会议语种:英文

页码: 1-5

在线出版日期: 2010-06-18（万方平台首次上网日期，不代表论文的发表时间）