A Molecular Model for Representing Protein Structures and its Application to Protein Folding
The protein folding problem is a central issue in Bioinformatics. It still represents a challenge for both Biology and Computer Science. Proteins are composed by up to hundreds of amino acids, each one with tenths of atoms. In general, a full representation of such structure and its interacting elements precludes computational simulations. This work proposes a molecular model for representing protein structures. This new model preserves some physico-chemical properties of the original protein and is aimed at allowing efficient computational simulations. A simulation of the model using a multiagents system is reported. Results so far suggest the adequacy of the proposed model for representing protein structures and their folding process with a reasonable complexity and suitable expressiveness.
Fernanda Hembecker Heitor Silvério Lopes
Bioinformatics Laboratory, Federal University of Technology Paraná Av.7 de setembro, 3165-80230-901 Curitiba, Brazil
国际会议
成都
英文
1-6
2010-06-18（万方平台首次上网日期，不代表论文的发表时间）