The Contribution of Polar Cortical actin and Microtubule to Cytokinesis at Early Anaphase

摘要：

Temporally and spatially regulating the microtubulecytoskeleton, the actin cytoskeleton and cortical myosin assemblyis primary to cell dividing. To realize the contribution of actinand microtubule in polar cortex at early anaphase, we locallyreleased cytochalasin D and colchicine in a highly localizedmanner to polar region of dividing normal rat kidney cells. Theresults showed that local release of CD or colchicine at the polarregion caused inhibition of cytokinesis at early anphase beforeingression. Cells treated with 30 μ M blebbistatin were used tocontrast to control. Our findings showed that disturbed polarcortical cytoskeleton not only inhibited initiation of cytokinesisbut also influenced the position of furrow. The results suggestedthe definitive roles of global coordination of cortical activities atearly anaphase.

作者: WANG Li AN Meiwen LI Xiaona

作者单位: Institute of Applied Mechanics and Biomedical Engineering,Taiyuan University of Technology,Taiyuan, China

会议类型: 国际会议

会议名称: The 4th International Conference on Bioinformatics and Biomedical Engineering(第四届IEEE生物信息与生物医学工程国际会议 iCBBE 2010)

会议地点: 成都

会议语种:英文

页码: 1-4

在线出版日期: 2010-06-18（万方平台首次上网日期，不代表论文的发表时间）