PREPARATION and CHARACTERIZATION of CHITOSAN MICROSPHERES ENCAPSULATING SUPERPARAMAGNETIC Fe3O4 NANOPARTICLES

摘要：

Chitosan microspheres (Chi-Fe microspheres)encapsulating superparamagnetic iron oxide nanoparticles(SPION, Fe3O4) were produced using a high voltage electrostaticfield system. The surface morphology and size of these preparedChi-Fe microspheres were examined using optical microscopyand scanning electron microscopy. The preliminarily resultsshowed that the size of the Chi-Fe microspheres was at the rangeof 600 μm in diameter, however, the surface morphologies couldbe changed by treating with different ratios of crosslinkingsolution. The formulation with ratio of 17:3 (Na5P3O10: NaOH)had a smoother surface and better mechanical strength. Theamount of SPION encapsulated increased the size of Chi-Femicrospheres and the minimum amount of SPION to havesignificant magnetization result was 1.68mg (30%). The Chi-Femicrospheres could be attracted (or moved) under the magneticfield.

作者: Benjamin Teong Shwu Jen Chang Ioannis Manousakas Shyh-Ming Kuo Li Chun Lin

作者单位: Department of Biomedical Engineering I-Shou University Kaohsiung, Taiwan Department of Electrical Engineering, Orthopedic Department Veteran General Hospital Kaohsiung, Taiw

会议类型: 国际会议

会议名称: The 4th International Conference on Bioinformatics and Biomedical Engineering(第四届IEEE生物信息与生物医学工程国际会议 iCBBE 2010)

会议地点: 成都

会议语种:英文

页码: 1-4

在线出版日期: 2010-06-18（万方平台首次上网日期，不代表论文的发表时间）