Preparation of glucan sulfates with different degree of substitution and their immunoprophylaxis potentials in Escherichia coli induced mice peritonitis

摘要：

Glucan sulfates with different degree of substitutionwere prepared from partially sulphated insoluble β -1,3-D-glucanisolated from Saccharomyces cerevisiae cell wall. Sulphation wasdone with sulfate acid (H2SO4) in dimethyl sulfoxide (DMSO) inpresence of urea. Varying reaction times, temperature and ratioof H2SO4 and DMSO were used to obtain glucan sulfates withdistinct degree of substitution, which was measured by bariumchloride-gelatin method. The immunoprophylaxis effect of glucansulfates in a mouse model of Escherichia coli induced peritonitiswas studied and found to be related to the degree of substitution.The result showed that as the degree of substitution increased,the immunoprophylaxis efficacy increased.

作者: Liping Du Hongyan Niu Xuekuang Zhang Dongguang Xiao

作者单位: Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology Tianjin University of Science and Technology Tianjin 300457, China

会议类型: 国际会议

会议名称: The 4th International Conference on Bioinformatics and Biomedical Engineering(第四届IEEE生物信息与生物医学工程国际会议 iCBBE 2010)

会议地点: 成都

会议语种:英文

页码: 1-4

在线出版日期: 2010-06-18（万方平台首次上网日期，不代表论文的发表时间）