Adhesive and In Vitro Release Properties of the Konjac Glucomannan and Xanthan Gum Mixture Gel Film
(0) Purposes: To study the adhesive and the in vitrorelease properties of a mixture gel film prepared with two kindsgum. Methods: The optimal formula was investigated by thequadratic regression rotatable orthogonal design with adhesiveforce as the evaluated parameter. Its in vitro release behaviorwas studied by the in vitro accumulative released curve withaciclovir as the model medicine. Results: By predication andverification, the optimal formula for film-forming wasdetermined as follows: 50 mL of mixture gel of 1 %(w/w)konjac glucomannan and 1 % (w/w) xanthan gum solution at theratio of 2.36:1 (v/v), added 0.35 mL of glycerol and 0.47 mL ofTween-80, the forming film possessed the optimal adhesiveability, and the adhesive force for each piece was (50.85±3.57)g (n=6). The release of aciclovir from the medicinal filmreached the maximum at 4.5 h, and could maintain 3-7 h.Conclusions: The konjac glucomannan and xanthan gum mixturegel film possesses good bio-adhesive and controlled-releaseabilities, and the results indicated that it could be a promisingmatrix material for the mucosa adhesive and transdermal drugdelivery systems.
ZHANG Ying-qing XIONG Wei-de MI Zhi-yuan MA Zhuo LI Xiao-li
Bioengineering College Hubei University of Technology Wuhan, China
国际会议
成都
英文
1-4
2010-06-18（万方平台首次上网日期，不代表论文的发表时间）