A Dual-frequency Loading Device For Tissue Engineering Cartilage
Cartilage degradation or defects cause joint pain,activity obstacles, or even completely losing the joint function. Atpresent, using many new technologies and methods for treatmentclinically, but it only relieves the patients of pain. Thedevelopment of cartilage tissue engineering is becoming an idealway of permanently repairing tissue defects. Mechanical factorsplay a major role during the cartilage growing and developping.Currently, a variety of mechanical conditions are applied tocartilage bioreactors, such as Fluid shear stress, Liquid Pressure,Direct compression etc., or some combinations of these. But thesemechanical conditions have not reflected the real mechanicalenvironment of the cartilage. According to the biomimicprinciple of tissue engineering, from the mechanicalcharacteristic of human activities, we have developed a dual-frequencyloading device using in cartilage culture, adoptingdual-frequency loading method.There are two frequencies andcorresponding amplitudes working on the building cartilage atany time, and it achieves that low-frequency high-amplitudecoupling high-frequency low-amplitude loads acting on artificialcartilage constructions, that is, under dual-frequency dynamicloading conditions. The kind of dual-frequency loading methodmaybe contribute to the construction of the cartilage. Thestructure size of the device is enough small to fit for working in the general culture box, and we will test it with biologicalexperiment in future.
Qiang Xu Chunqiu Zhang Yubo Fan Han Wu Shuqing Zhang
School of Mechanical Engineering, Tianjin University of Technology ,Tianjin Key Laboratory for Contr School of Mechanical Engineering, Tianjin University of Technology ,Tianjin Key Laboratory for Contr Department of Bioengineering, Beihang University,Beijing, China China-Japan Friendship Hospital, Jilin University Changchun , China
国际会议
成都
英文
1-3
2010-06-18（万方平台首次上网日期，不代表论文的发表时间）