Transmission SPR of Gold Nanoslit Array and Ultrasensitive Detection of A Retinol Binding Protein

摘要：

Retinal-modified SAM-coated nanoslit array thin goldfilm was used for ultra-sensitive (picomolar) detection of a ligandprotein (β -Lactoglobulin) with a transmission SPR mode. Thetransmission spectra of nanoslit arrays with varying periods wereevaluated for nanostructure optimization with respect to primarypeak position, shape and sensitivity. Sensitivity of this method, asmeasured in water, was estimated at 3 ng/mL, or approximately130 picomolar. Additionally a monotonic shift in primary peakwavelength was observed with changing nanoslit periodicity. Thistype of in-plane nanoarray chip is currently being integrated withmicrofluidic platforms for chemical and/or biological sensingapplications.

作者: Jianjun Wei Sameer Singhal Matthew Kofke David H.Waldeck

作者单位: Biomedical Technology CFD Research Corporation Huntsville, AL 35805, USA The Department of Chemistry University of Pittsburgh Pittsburgh, PA 15260, USA

会议类型: 国际会议

会议名称: The 4th International Conference on Bioinformatics and Biomedical Engineering(第四届IEEE生物信息与生物医学工程国际会议 iCBBE 2010)

会议地点: 成都

会议语种:英文

页码: 1-4

在线出版日期: 2010-06-18（万方平台首次上网日期，不代表论文的发表时间）