Mass Production of Monodisperse Ultrasound Contrast Microbubbles in Integrated Microfluidic Devices
Microbubbles coated by surfactant or polymer have been shown to be the most effective contrast agents for diagnosticultrasound contrast imaging and targeted molecular imagingprobes. The microbubbles produced by flow-focusing units havea narrower size distribution than that of the traditional methodssuch as sonication or agitation and is nearly monodisperse in sizedistribution, but with very limited production. This paperinvestigates the production of monodisperse microbubbles inintegrated microfluidic devices in a massive way. The integratedmicrofluidic devices are composed of three layers: two top layersmade from poly(dimethylsiloxane)(PDMS) and one glass slide as the bottom layer. Four and eight FFUs are integrated on a chipsharing the same gas inlet, liquid inlet and outlet channel.Monodisperse microbubbles production efficiency of the threemicrofluidic devices with one, four and eitht FFUs on a chip areevaluated respectively. It is found that the liquid consumptiondoes not increase linearly with the FFUs number withinmicrofluidic devices while the concentration of the microbubblesincreases. The results of this work indicate the potential for massproduction of ultrasound contrast agents in large scale integratedmicrofluidic device for commercial use.
Chunxiang Jiang Xiang Li Qiaofeng Jin Tan Chen Zhanhui Wang Hairong Zheng
Paul C.Lauterbur Research Centre for Biomedical Imaging Key Laboratory of Biomedical informatics and CAS/CUHK Research centre for Biosensors and Medical Instruments Key Laboratory of Biomedical informa
国际会议
成都
英文
1-4
2010-06-18（万方平台首次上网日期，不代表论文的发表时间）