A MEG Study Of Gamma Oscillations During Unilateral Movement
Recent studies have found the consistent contralateralhigh gamma activities in sensorimotor cortex in adults during aunilateral finger movement. However, no study has ever reportedthe same phenomenon in children. We hypothesized that thecontralateral high gamma activities also exist in children duringa unilateral finger movement. Sixty normal children (6-17 yearsold) were studied with a 275-channel MEG system combined withsynthetic aperture magnetometry (SAM). Sixty participantsdisplayed consistently contralateral event-relatedsynchronization (C-ERS) within high gamma band (65-150Hz) inprimary motor cortex (M1) of both hemispheres. Interestingly,nineteen younger children displayed ipsilateral event-relatedsynchronization (I-ERS) within the high gamma band (65-150Hz)just during their left finger movement. Both I-ERS and C-ERSwere localized in M1. The incidence of I-ERS showed asignificant decrease with age. Males had significantly higher oddsof having ipsilateral activity compared to females. Noteworthy,high gamma C-ERS appeared consistently, while high gamma I-ERSchanged with age. The asymmetrical patterns ofneuromagnetic activities in the childrens brain might representthe maturational lateralization and/or specialization of motorfunction. In conclusion, the present results have demonstratedthat contralateral high-gamma neuromagnetic activities are thepotential biomarkers for the accurate localization of the primarymotor cortex in children. In addition, the interesting finding of the ipsilateral high-gamma neuromagnetic activities open a newwindow for us to understand the development changes of thehemispherical functional lateralization in the motor system.
Xiaolin Huo Jing Xiang
Institute of Electrical Engineering,Chinese Academy of Sciences Beijing, China Department of Neurology, Cincinnati Childrens Hospital Medical Center, Cincinnati, Ohio, USA
国际会议
成都
英文
1-4
2010-06-18（万方平台首次上网日期，不代表论文的发表时间）