Investigation of Early Liver Radiation Injury Using Resovist-Enhanced MRI at 3T
The aim of this study was to investigate the rat liverinjury caused by radiation using contrast enhanced magneticresonance imaging (MRI) at 3T. The contrast agent used wasResovist, a kind of commercialized superparamagnetic iron oxide(SPIO). SPIO particles can be macrophaged by Kupffer cellsafter intravenous injection. The macrophaged SPIO particlesmake the MR signal decrease because of the susceptibility effect.When liver has injury caused by radiation, the macrophagefunction of Kupffer cells decreases. Once the Kupffer cellsmalfunction, the MR signal of irradiated liver decreases less thannormal liver after SPIO administration. Therefore, liverradiation injury can be detected. The MR signal enhancementvaries with the magnetic field strength, pulse sequences, injectedSPIO doses and duration after SPIO injection. Three to four daysafter rats liver was irradiated with 30 Gy X-ray, the MR signalenhancement of rat liver at 3T after 80 μmol/kg body weightResovist injection was investigated in this study.
Jo-Chi Jao Hsin-Ying Lu Hsiang-Chin Lu Shi-Long Lian Gin-Chung Liu Shih-Hsie Chen Sheau-Fang Yang Po-Chou Chen
Department of Medical Imaging and Radiological Sciences Kaohsiung Medical University Kaohsiung, Taiw Department of Oncology Kaohsiung Medical University Hospital Kaohsiung, Taiwan, R.O.C. Department of Medical Imaging Kaohsiung Medical University Hospital Kaohsiung, Taiwan, R.O.C. Department of Pathology Kaohsiung Medical University Hospital Kaohsiung, Taiwan, R.O.C. Department of Medical Imaging and Radiological Sciences I-SHOU University Kaohsiung, Taiwan, R.O.C.
国际会议
成都
英文
1-4
2010-06-18（万方平台首次上网日期，不代表论文的发表时间）