A New Signal Processing Method Based on Doppler Effect for Targeted Ultrasound Contrast Agent Imaging
Targeted ultrasound molecular imaging technology isemerging as a novel imaging modality that shows initial successesin sensitive detecting of inflammation, heart transplant rejection,thrombus and angiogenesis. In the targeted imaging, one challengeis to detect the signal from targeted contrast microbubles. Thepaper presents a new targeted contrast agent imaging methodwhich could differentiate adherent and free agents effectively byusing Doppler frequency shift. The Doppler frequency shift isemployed to analysis the flowing bubble signal and stationarybubble signal. The Doppler shift frequency can be calculated due to the reflecting central frequency and bandwidth in addition to thevelocity of the free bubble controlled by a syringe pump in theexperiment. The wall filter is applied for filtering the signal thatbrings up the Doppler shift frequency. By using the method,experimental study shows compressed the free contrast agent andtissue signals while leaving the targeted bubble signal unaffected.
Qian Wang Hairong Zheng
Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Lauterbur Biomedical Imaging CAS/CUHK Research centre for Biosensors and Medical Instruments, Institute of Biomedical and Health
国际会议
成都
英文
1-4
2010-06-18（万方平台首次上网日期，不代表论文的发表时间）