Application of an Improved RESS Process for Atractylodes macrocephala Koidz volatile oil Liposomes Production
To improve the bioavailability and targeting effect tohepatic cells of volatile oil from Atractylodes macrocephalaKoidz, the volatile oil was incorporated into liposomes by aimproved process of rapid expansion of supercritical solutions(RESS). In this process, the liposomal materials and the volatileoil were dissolved in the mixture of supercritical carbon dioxide(SC-CO2)/ethanol and then the solution was sparyed into a buffersolution through a coaxial nozzle to form liposomessuspension.The physicochemical properties of the liposomesincluding structure, size of particle, entrapment ratio and loadingefficiency were measured. The encapsulating performance ofliposomes could be controlled by changing expansion processconditions such as pressure, temperature of SC-CO2 and theamount of cosolvent in SC-CO2 x (CH3CH2OH). Under theoptimum conditions of 30MPa, 338K and x (CH3CH2OH)=15 %,the entrapment efficiency, drug loading, and average particle sizeof liposomes were found to be 82.18 %, 5.18 % and 173 nmrespectively, which were complied with the standards of Chinesepharmacopoeia. The results indicate the improved RESStechnique provide an innovative way for formation of liposomesloading multi-components extracted from Chinese traditionalmedicines.
Zhen Wen Xinkui You Bo Liu Zongkun Zheng Yitao Pu Qiong Li
School of chemistry and chemical engineering,Shenzhen University Shenzhen, Guangdong 518060, China School of chemistry and chemical engineering,South China University of Technology Guangzhou 510640,
国际会议
成都
英文
1-4
2010-06-18（万方平台首次上网日期，不代表论文的发表时间）