Fluorophore analyses of vulnerable atherosclerotic plaque and its early detection
The diagnosis of atherosclerotic plaque based on timeresolved laser-induced fluorescence spectroscopy and the relationship of the endogenous fluorophores in lesions with the wavelength-resolved and especially the time-resolved data were investigated. The major fluorophores in arterial tissues are elastin and collagen (type I and III), and lipid components such as free cholesterol, cholesterol esters and LDLs. Elastin which has broad spectral emission is the primary fluorophore in normal artery, whereas collagen which has narrow band and blue-shifted peak emission and the highest lifetime is the mainly fluorophore in collagen-rich plaques. Lipid components that have the fastest fluorescence dynamics mainly exist in lipid-rich lesions which are always instability. At last a dual-modality system combined two complementary techniques was also introduced to diagnose vulnerable plaques.
Yang Shen Hairong Zheng Han Cui Lei Jin Lintao Cai Y.T.Zhang
Paul C.Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineer Paul C.Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineer Key Laboratory of Biomedical informatics and Health Engineering Chinese Academy of Sciences Shenzhen
国际会议
成都
英文
1-4
2010-06-18（万方平台首次上网日期，不代表论文的发表时间）