Study of Epileptiform Discharges in Hippocampal Slices Using Multi-channel Recording System

摘要：

Understanding the initiation site of epileptiform discharges in hippocampus are of important physiological significance. Here in transverse plane of hippocampus, the above questions were investigated with low-Mg2+artificial cerebrospinal fluid (ACSF) perfused hippocampal slices of Sprague Dawley rat using microelectrode arrays. Initiation site of epileptiform discharges was determined by comparing the onset time of field potentials as well as calculating the cross-correlation of multiunit action potentials. Time delay of epileptiform discharges between the initiation site and the other regions was obtained. The result indicates that epileptiform discharges originate from CA3b region in the hippocampal slice.

作者: Xin-Wei Gong Fan Yang Jian-Sheng Liu Qin-Chi Lu Hai-Qing Gong Pei-Ji Liang Pu-Ming Zhang

作者单位: School of life sciences and biotechnology Shanghai, China School of Medicine Shanghai Jiao Tong University Shanghai, China

会议类型: 国际会议

会议名称: The 4th International Conference on Bioinformatics and Biomedical Engineering(第四届IEEE生物信息与生物医学工程国际会议 iCBBE 2010)

会议地点: 成都

会议语种:英文

页码: 1-4

在线出版日期: 2010-06-18（万方平台首次上网日期，不代表论文的发表时间）