A mathematical model for anti-HBV infection combination therapy with Peginterferon Alfa-2a and Lamivudine

摘要：

Based on the clinical date of the Peginterferon Alfa-2a plus Lamivudine (combination therapy) for HBeAg-Positive chronic hepatitis B patients, this paper sets up a mathematical model consisting of two differential equation systems that enable us to describe and understand the dynamics of host cells, virus and the immune system. Our model provide a possible interpretation for the effect of combination therapy to the chronic HBV infection patients. In particularly, we can account for the phenomenon of HBV DNA load returned after stopping the therapy. Numerical simulations show that if we proceed with the treatment 6.8 years, the HBV virus will be completely eliminate in infected heptocytes.

作者: Guo Zhang Hong Zhao Qizhi Xie

作者单位: Graduate School Tianjin Polytechnic University Tianjin, China, 300160 School of Science Tianjin Polytechnic University Tianjin, China, 300160

会议类型: 国际会议

会议名称: The 4th International Conference on Bioinformatics and Biomedical Engineering(第四届IEEE生物信息与生物医学工程国际会议 iCBBE 2010)

会议地点: 成都

会议语种:英文

页码: 1-4

在线出版日期: 2010-06-18（万方平台首次上网日期，不代表论文的发表时间）