Preparation and release dynamic of ibuprofen polymeric prodrug with glucose pendant
A kind of polymeric prodrug of ibuprofen with glucose pendant was prepared through chemo-enzymatic method. The obtained polymeric prodrug was characterized by FT-IR, NMR and GPC. The molecular weight of the polymeric prodrug reached 2.126× 104. Furthermore, the in vitro release behaviors of ibuprofen (raw drug) and the polymeric prodrug were investigated in pH 7.4 buffer solution at 37 ℃. It was suggested that low-molecular-weight ibuprofen was fast released and the cumulative release amount was almost 100% after 3 h, while only about 4 % of parent drug was released from polymeric prodrug in the same time. The continuous release investigation showed that the cumulative parent drug amount released from the polymeric prodrug reached 32% after 10 days. Compared to the raw drug, the polymeric prodrug of ibuprofen with glucose pendant had a better effect of prolonged release, and the release of ibuprofen from polymeric prodrug exhibited first order kinetic equation.
Cheng-Yao Wu Jing Quan Jian-Gang Xie Li-Min Zhu J Branford-White
College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, P.R.Chin College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, P.R.Chin Institute for Health Research and Policy London Metropolitan University, London, UK
国际会议
成都
英文
1-4
2010-06-18（万方平台首次上网日期，不代表论文的发表时间）