In Vivo Antioxidant Activity of Black Glutinous Corncob Pigment
In this paper, the antioxidant activity of black glutinous corncob pigment (BGCP) on D-galactose-induced aged mice is described. The animals were divided into five groups: (1) aged group; (2) normal group; (3) low dose group; (4) medium dose group; and (5) high dose group. After 35 days, the mice were killed and the following parameters were measured in the serum, brain, and liver: malondialdehyde (MDA) concentration, superoxide dismutase (SOD) activity, and glutathione peroxidase (GSH-PX) activity. The results indicated that BGCP increased GSH-PX and SOD activities, and decreased MDA concentration. The indices of GSH-PX, MDA, and SOD in the low, medium, and high dose mice, which were injected with D-galactose, approached the levels of normal mice. However, the indices of GSH-PX, MDA, and SOD between the low, medium, and high dose mice were significantly different (P < 0.05) from the aged group of mice. There was a direct correlation between BGCP concentration and SOD and GSH-PX activities, and an inverse correlation between BGCP concentration and MDA concentration. Therefore, BGCP can inhibit the decrease of GSH-PX and SOD activities and the increase of MDA concentration in the serum, brain, and liver of mice induced by D-galactose, and improve the antioxidant activity of aging mice.
Zhong Zhang Jian-Jie Wang Ye Hua Zhi-Mou Gao Song-Shan Qiu Ling Zhang Cui-Cui Jiang
College of Chemistry and Life Science, Maoming University, Maoming 525000, China College of Engineering, Anhui Science and Technology University, Fengyang 233100, China Anhui Agricultural University, Hefei 230036, China
国际会议
成都
英文
1-4
2010-06-18（万方平台首次上网日期，不代表论文的发表时间）