The effects of oat β-glucan on the hypoglycemic of type 2 diabetic mice
Background: In recent years, most of the studies focused on oat bran and the food of oat containing β-glucan that could bring about hypoglycemic effects, while only a few studies paid attention to the functions of oat β-glucan, in addition , there was much controversy about the effective dose of oat β-glucan in humans with type 2 diabetes. Objective: To evaluate the association between the oat β-glucan and type 2 diabetes and decide the optimal dose after taking of different doses of oat β-glucan extraction (from the oat bran of Shanxi, and the content is 82.10%). Design: Male KM mice (n=100) were randomly divided into two groups within a randomized design after adaptive feeding for 3 days, the normal control group (NC, n=15) was kept with chow diets and the model group (n=85) was fed high-fat diets. The model of type 2 diabetic mice was successful, then oral administration of oat β-glucan at 800 mg/kg·bw, 1200 mg/kg·bw and 2000 mg/kg·bw up to 6 weeks. Methods: The type 2 diabetic mice resulted from high fat and Streptozotocin (STZ).Decide the adequate levels of oat β-glucan by many measures, such as fasting/postprandial blood glucose(FBG/PBG) 、fasting blood insulin(Fins) 、Insulin activity index （IAI） and oral glucose tolerance test(OGTT). Results: Oat β-glucan can remarkably reduce the FBG/PBG and stimulate insulin secretion, as well as improve the ability of glucose tolerance (p<0.01).And the best dose is 2000mg/kg·bw. Conclusions: The results showed that oat β-glucan might alleviate diabetic symptoms and improve the sensitivity of insulin in diabetic mice.
Ruiling shen Fengli Cai
School of Food and Biological Engineering Zhengzhou Institute of Light industry Zhengzhou, China
国际会议
成都
英文
1-4
2010-06-18（万方平台首次上网日期，不代表论文的发表时间）