Metabolism of Toluene Diisocyanate in Mice Testis and Epididymis

摘要：

To elucidate the metabolism of toluene diisocyanate (TDI) in mice testis and epididymis, the metabolism was studied in vivo. By using of HPLC, the linear range, recovery and metabolic constants in mice testis and epididymis were studied. As result, both the metabolism of TDI in the testis and the epididymis were matched to the first order dynamic equation, and the average recovery was more than 96%. There were metabolites with toxicity in the metabolism of TDI in mice testis and epididymis, which provided a basis for the reproductive toxicity of TDI.

作者: Lei YU Lin-jing SHEN Yu-bin JI

作者单位: Center of Research on Life Sciences and Environmental Sciences Harbin University of Commerce Harbin, Engineering Research Center of Natural Anticancer Drugs Ministry of Education Harbin, China

会议类型: 国际会议

会议名称: The 4th International Conference on Bioinformatics and Biomedical Engineering(第四届IEEE生物信息与生物医学工程国际会议 iCBBE 2010)

会议地点: 成都

会议语种:英文

页码: 1-5

在线出版日期: 2010-06-18（万方平台首次上网日期，不代表论文的发表时间）