Acute toxicity of different sized ZnO nanoparticles in mice after intratracheal administration

摘要：

Acute toxicity of different sized (10, 30 and 100nm) ZnO particles was investigated by intratracheal injection at the dose of 0.05 and 0.5g/kg body weight. The results of biochemical parameters assay, pathological examination and zinc accumulation showed main target organs for ZnO particles are demonstrated as lung, spleen, pancreas, bone and liver after exposure by intratracheal injection. But the toxic effects between different sized and dose ZnO particles are a little different. The toxicity of ZnO nanoparticles exhibited a dose-effect relationship. At low dose, three sized ZnO particles induce slight damage, and 10nm ZnO particles lead to relatively serious lung and liver damage. At high dose, 30nm ZnO particles result in worse lung, liver and pancreas injury. Furthermore, ZnO nanoparticles led to oxide stress, which may be an important reason for injury induced by ZnO particles.

作者: Wenhua Song Jinhua Zhang Jinyang Zhang

作者单位: School of Environmental and Chemical Engineering Tianjin Polytechnic University Tianjin, China Colle School of Environmental and Chemical Engineering Tianjin Polytechnic University Tianjin, China College of Environmental Science and Engineering Shanghai Jiaotong University Shang hai, China

会议类型: 国际会议

会议名称: The 4th International Conference on Bioinformatics and Biomedical Engineering(第四届IEEE生物信息与生物医学工程国际会议 iCBBE 2010)

会议地点: 成都

会议语种:英文

页码: 1-4

在线出版日期: 2010-06-18（万方平台首次上网日期，不代表论文的发表时间）