Study on Reversibility of Genetic Toxicity of TDI in Mice

摘要：

This article studied whether genetic toxicity of toluene diisocyanate was reversible. Kunming mice were exposed to TDI by respiratory tract for 14 days in 1/8LC50, 1/4LC50 and 1/2 LC50 dosage and then were feed normally for 14 days. The chromosomal aberrations and the content of RNA & DNA were detected by optical microscope and laser scanning confocal microscope. In 1/4LC50 and 1/2 LC50 group, chromosome aberration rate and the RNA /DNA ratio of TDI were higher than control group significantly (P<0.01). In addition there was no significant difference between 1/4LC50 and 1/2 LC50 (p> 0.05). The results showed that the damage of TDI on chromosomes and DNA was repairable, but can not be repaired completely.

作者: Yu-bin JI Miao YU Lei YU Wen YANG Ying-jie YANG

作者单位: Center of Research on Life Sciences and Environmental Sciences Harbin University of Commerce Harbin, Engineering Research Center of Natural Anticancer Drugs Ministry of Education Harbin, China

会议类型: 国际会议

会议名称: The 4th International Conference on Bioinformatics and Biomedical Engineering(第四届IEEE生物信息与生物医学工程国际会议 iCBBE 2010)

会议地点: 成都

会议语种:英文

页码: 1-4

在线出版日期: 2010-06-18（万方平台首次上网日期，不代表论文的发表时间）