Evaluation of Estrogenic Activity of Cadmium to Mice in Organic and Molecular Level

摘要：

Cadmium, as an inorganic pollutant, its toxic effects on mammals were widely studied, while less attention was paid on its endocrine disrupting effects. In this paper, the effects of CdCl2 on mice uterine-ovary wet weight, modulation of ER (estrogen receptors) mRNA level and their relation were studied. It showed that uterus-ovary wet weight, the expression of Erα(α subtype) and ER (subtype) were of significant the control. However, only up-regulation of ER was detected in expression of ER might protect mice from increasing of uterus-ovary wet weight. For CdCl2 estrogenic activity, the ER expression mechanism and ER-responsive elements pathway need further examination.

作者: Qiaoqiao Zhou Wen Mu Xue Yang Can Zhang Xiaojing Hu Zhen He Li Xiong Deli Liu

作者单位: Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University, Wuhan, China,430079

会议类型: 国际会议

会议名称: The 4th International Conference on Bioinformatics and Biomedical Engineering(第四届IEEE生物信息与生物医学工程国际会议 iCBBE 2010)

会议地点: 成都

会议语种:英文

页码: 1-4

在线出版日期: 2010-06-18（万方平台首次上网日期，不代表论文的发表时间）