Study on the DNA damage of rat lung cells induced by Butylbenzyl phthalate

摘要：

To study the effect of Butylbenzyl phthalate inducing DNA damages in Rat lung cells. KCl-SDS assay and comet assay were used to reveal the amount of DNA-protein crosslinks and effect of DNA damages induced by different doses of Butylbenzyl phathalate in vitro. The results showed that Butylbenzyl phathalate could cause DNA breakage at low level (10 μmol/L, P<0.01), while at higher level (40 μmol/L, P<0.01; 160 μmol/L, P<0.01) it caused crosslinks obviously. In conclusion, higher levels BBP induced significant oxidative damage, and then caused damages to DNA.

作者: Wang Jing Li lan Cai Feng-yun Zeng Qiang Yang Xu

作者单位: Hubei Key Laboratory of Genetic Regulation and Integrative Biology College of Life Science, Huazhong Normal University, Wuhan 430079, China

会议类型: 国际会议

会议名称: The 4th International Conference on Bioinformatics and Biomedical Engineering(第四届IEEE生物信息与生物医学工程国际会议 iCBBE 2010)

会议地点: 成都

会议语种:英文

页码: 1-3

在线出版日期: 2010-06-18（万方平台首次上网日期，不代表论文的发表时间）