Oxidative Damage of Decabromodiphenyl Ether (BDE209) on the Hepatic Cells of Rat in vitro
Owing to its good flame-retardant effect, polybrominated diphenyl ethers (PBDEs) were widely added to electronic, electrical appliances, as well as textiles and chemical products. Decabromodiphenyl Ether (BDE-209) is one class of PBDEs which was most demanded in international market. To illustrate the possible function of BDE-209 on rat liver, hepatic cells were expose to BDE-209 with different concentrations (1, 2, 4, 8, 16 mg?L -1) in vitro, the contents of malondialdehyde (MDA) and the levels of DNA-protein crosslinks (DPC) were investigated. The results indicated that: with the BDE-209 exposure concentrations increased, MDA content and DPC coefficient increased gradually, showed almost the same trend. Significant difference was observed in both MDA content and DPC coefficient in the 4 ,8 and 16 mg?L -1 (P<0.05) groups compared to the control group, while extremely significant difference was observed in the 16 mg?L -1 groups (P<0.01). Moreover, MDA content has a good dose-response relationship with the BDE-209 exposure concentrations(R=0.995, P<0.05), so does DPC (R=0.996, P<0.05). The results suggested that the BDE-209 exposure can cause oxidative stress and genetic toxicity to rat liver, demonstrating hepatotoxic effect as well as genetic effect to the body.
Yao Wen-hao Jiang Ming-di Hu Qin-qin Li Ren Yang Xu
Laboratory of Environmental Sciences College of Life Science, Huazhong Normal University Wuhan 430079, China
国际会议
成都
英文
1-4
2010-06-18（万方平台首次上网日期，不代表论文的发表时间）