Stochastic resonance algorithm for enhancement of signal-to-noise ratio of HPLC/MS signal

摘要：

Based on the theory of stochastic resonance, a new method was presented to enhance signal-to-noise ratio (SNR) of HPLC/MS signal for trace analysis with a new optimization method of the system parameters. The method was applied to experimental weak signals of HPLC/MS, which was embedded in the noise background and the SNR was enhanced greatly. The LOD and LOQ were improved from 10 ng/ml and 25 ng/ml to 2 ng/ml and 5 ng/ml, respectively. The results showed an excellent quantitative relationship between concentrations and chromatographic responses.

作者: Chang-Yun Chen Shao-Fei Xie Hai-Shan Deng Bing-Ren Xiang

作者单位: Department of Chemistry, Nanjing Xiaozhuang University Nanjing 211171, P.R.China Guangzhou Institute for Drug Control 23 Xizeng Road, Guangzhou 510160 ,P.R.China Center for Instrumental Analysis, China Pharmaceutical University Nanjing 210009, P.R.China

会议类型: 国际会议

会议名称: The 4th International Conference on Bioinformatics and Biomedical Engineering(第四届IEEE生物信息与生物医学工程国际会议 iCBBE 2010)

会议地点: 成都

会议语种:英文

页码: 1-3

在线出版日期: 2010-06-18（万方平台首次上网日期，不代表论文的发表时间）