Measurement of residual solvents in thiamine hydrochloride by static headspace gas chromatography

摘要：

A rapid general method for the determination of residual solvents in thiamine was studied. This paper demonstrated static headspace gas chromatography (HS/GC) with either flame ionization detection (FID) or mass spectrometry (MS) for the determination of volatile residual solvents in pharmaceutical products. The analytical method performance characteristics were investigated, including the repeatability, the accuracy and the detection limit of determination. The results showed that the method had very good sensitivities (detection limits under 9.45 μg/mL) and precision (under 7.35% RSD) for all solvents. The rates of recovery were 98.59%, 95.25%, 103.89% and 99.88% for methanol, ethanol, N, N-dimethyllformamide and ethyl ether, respectively.

作者: Wenhua song Minling Gao Jing Guo Ting Sun

作者单位: School of Environmental and Chemical Engineering Tianjin Polytechnic University Tianjin, China

会议类型: 国际会议

会议名称: The 4th International Conference on Bioinformatics and Biomedical Engineering(第四届IEEE生物信息与生物医学工程国际会议 iCBBE 2010)

会议地点: 成都

会议语种:英文

页码: 1-4

在线出版日期: 2010-06-18（万方平台首次上网日期，不代表论文的发表时间）