DISTINCT BIOPHYSICAL CHANGES CAUSED BY THE ADDITION OF IODINE ATOMS IN DEGRADABLE AMORPHOUS BIOMATERIALS
X-ray based fluoroscopy and imaging are the preferred imaging modalities for assessing correct device placement and function following surgical implantation. Imaging polymeric constructs under clinically preferred conditions is complicated in that most polymeric materials are amorphous and possess very low X-ray scattering cross-sections. Iodine is routinely incorporated into amorphous polymeric materials to increase the X-ray contrast but this process cause distinct physico-chemical changes in the material, which in turn can have a variety of biological implications, including changing the nature of the adsorbed protein layer. To assess influence of iodine incorporation of the cellbiomaterial interactions including protein adsorption, a blending strategy was designed to minimizing the amount of iodine necessary within the polymers for X-ray based imaging.
Khaled A.Aamer Joachim Kohn Matthew L Becker
Polymers Division, NIST, Gaithersburg, MD 20899 New Jersey Center for Biomaterials, Piscataway, NJ 08854 Department of Polymer Science, University of Akron, 170 University Ave
国际会议
PP’2010，Jinan International Symposium on Polymer Physics(2010济南国际高分子物理学术研讨会)
济南
英文
117
2010-06-06（万方平台首次上网日期，不代表论文的发表时间）