STUDY ON THE SLIDING FRICTION OF ENDOTHELIAL CELLS
1. Introduction In the in vivo vascular systems, the inner surface of blood vessel is covered by a functional endothelial cell (EC) monolayer. ECs are shielded from direct exposure to flowing blood by a layer of macromolecules known as the glycocalyx. It is interesting to observe that the red blood cells (8 μm) deform and smoothly squeeze through capillaries with a substantially smaller diameter (5~6 μm) than their own. In this process, low friction should occur between the soft ECs (Youngs modulus: c.a. 0.2~8 kPa) and the deformable red blood cells (force per unit length of deformation: c.a. 3~10× 10~(-6) N/m). We consider that low friction is a critical function of ECs cultured on the inner wall of artificial blood vessel. However, to our knowledge, the effect of glycocalyx on the friction of ECs is unclear. Hydrogels are expected as scaffolds for repairing and regenerating a wide variety of tissues and organs, due to their three-dimensional network structure and viscoelasticity, which are similar to the macromolecular-based extracellular matrix in biological tissues. In this study, we describe experiments designed to study the on the friction of endothelial cells cultured on hydrogels. The study is help for designing hybrid artificial blood vessel with functional ECs.
Yong Mei Chen Takayuki Kurokawa Taiki Tominaga Kazunori Yasuda Yoshihito Osada Jian Ping Gong Kimiko Yamamoto Joji Ando
MOE Key Laboratory for Non-equilibrium Condensed Matter and Quantum Engineering, Department of Chemi Graduate School of Science, Hokkaido University, Sapporo 060-0810, Japan Graduate School of Science, Hokkaido University, Sapporo 060-0810, Japan RIKEN 2-1, Hirosawa, Wako, School of Medicine, Hokkaido University, Sapporo 060-0810, Japan RIKEN 2-1, Hirosawa, Wako, Saitama, 351-0198, Japan
国际会议
PP’2010，Jinan International Symposium on Polymer Physics(2010济南国际高分子物理学术研讨会)
济南
英文
146-147
2010-06-06（万方平台首次上网日期，不代表论文的发表时间）