SURFACE PROPERTY OF PEG-PLA DIBLOCK COPOLYMERS 2
Poly(lactic acid) (PLA), as a kind of biodegradable polymer, is expected to be well applied in tissue engineering. However, PLA exhibits a poor adhension to cells by reason of its hydrophobiciry. In order to improve hydrophilicity of PLA, an effective method is to introduce hydrophilic components to this material. Poly (ethylene glycol) (PEG) is well known for its hydrophilicity, lack of toxicity and excellent biocompatibility. It could be combined chemically into polymeric systems to improve the hydrophilicity of polymers. So study of amphiphilic block copolymer of PEG-PLA is much attractive. In this work, a series of PEG and PLA diblock copolymers with various chain length of PLA were synthesized by ring-opening polymerization of D,L-lactide in the presence of mono-hydroxyl poly(ethylene glycol). The resulting diblock copolymers (MPEG-PLA) with a fixed PEG segment of 2 kDa were characterized by H-NMR and water contact angle (CA). The number-average molecular weight (M_n) of MPEG-PLA diblock copolymers was calculated by the integration of the typical peak values in the H-NMR spectra (Figure 1). Table 1 gives a survey on the synthesized MPEG-PLAs copolymers. According to their composition, the PEG content of these polymers varies from 2.2 to 23.6%. Water contact angles measured on the corresponding MPEG-PLA coating surfaces decrease from 73 ° to 56°.
Bingjian Yao Oingzeng Zhu Hui Liu Ruofei Hu Yuanying Hu Lei Gao
Key Laboratory of Special Functional Aggregated Materials, Ministry of Education, School of Chemistr Key Laboratory of Special unctional Aggregated Materials, Ministry of Education, School of Chemistry
国际会议
PP’2010，Jinan International Symposium on Polymer Physics(2010济南国际高分子物理学术研讨会)
济南
英文
211-212
2010-06-06（万方平台首次上网日期，不代表论文的发表时间）