RATIONAL DESIGN OF PHOTORESPONSIVE DNA WITH CARTRIDGE-TYPE NUCLEOTIDE
1. Introduction Recently, DNA has come to be regarded not only as a carrier of genetic information but as an excellent nanomaterial that can perform mechanical motions as well as construct static nanostructures in a predetermined fashion due to its simple hybridization rule. However, since achievable performance is still limited with only four natural nucleotides, a variety of functional DNAs involving non-natural molecules have been proposed. We have developed photoresponsive DNAs involving azobenzenes on acyclic threoninols as scaffolds, and the key feature of DNA, the formation and dissociation of DNA duplexes, can be efficiently photoregulated to create a photon-driven nanomachine as well as photoswitching of enzymatic reactions.
Hirovuki Asanuma
Department of Molecular Design and Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan CREST JST, Kawaguchi, Saitama 332-0012, Japan
国际会议
International Symposium on Polymer Chemistry(第四届国际高分子化学学术研讨会 PC 2010)
苏州
英文
68-69
2010-06-02（万方平台首次上网日期，不代表论文的发表时间）