B-CYCLODEXTRIN-BASED POLY(N-(2-HYDROXYPROPYL)METHACRYLAMIDE) STAR POLYMERS FOR ACID-LABILE DRUG CONJUGATION AND MR IMAGING
In recent years, there has been tremendous amount of research into the use of multifunctional polymers for simultaneous imaging and therapy. The combination of molecular imaging and drug delivery on the same polymer platform will result in more effective imageguided therapies, which offer the possibility of increased diagnostic accuracy and therapeutic effectiveness, while minimizing side effects in treatment. Many biocompatible synthetic polymers have been used as a platform for the modification of pharmacokinetics of small molecular drugs and imaging agents to improve their efficiency in drug delivery and molecular imaging.1 Both drug delivery and molecular imaging can benefit from the large sizes, physiological compatibility, and unique pharmacokinetic properties of biomedical polymers. Thus, the design and synthesis of polymers containing both medical imaging agents and therapeutic drugs should be of great importance.
Xiaoiie Li Yinfeng Qian Shiyong Liu
CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui 230026, China, and The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
国际会议
International Symposium on Polymer Chemistry(第四届国际高分子化学学术研讨会 PC 2010)
苏州
英文
322-323
2010-06-02（万方平台首次上网日期，不代表论文的发表时间）