Electrospun thermoplastic polyurethane with anisotropic mechanical properties as biomedical scaffold
To design an ideal scaffold for tissue engineering, various factors should be considered, such as pore size and morphology, mechanical properties versus porosity, surface properties and appropriate biodegradability. Tissue engineered constructs must exhibit tissue-like functional properties. Electrospun thermoplastic polyurethane (ES-TPU) is elastomeric and allow for control of the fiber diameter, porosity and degradation rate. ES-TPU scaffolds can be fabricated to have a well-aligned fiber network, which is important for applications involving mechanically anisotropic soft tissues. We developed ES-TPU scaffolds under variable speed conditions and measured fiber alignment by fast Fourier transform (FFT). By using FFT to assign relative alignment values to an electrospun matrix, it is possible systematically evaluate how different processing variables affect the structure and material properties of a scaffold. TPU was suspended at certain concentrations and electrospun from 1,1,1,3,3,3,-hexafluoro-2-propanol (HFP) onto rotating mandrels (200~3000RPM). Scaffold anisotropy developed as a function of fiber diameter and mandrel RPM. The induction of varying degrees of anisotropy imparted distinctive material properties to the electrospun scaffolds.
CHEN Rui KE Qinfei MO Xiumei MORSI Yos
College of textiles, Donghua University, Shanghai201620, P.R.China College of chemistry and chemical engineering and biological engineering, Donghua University,Shangha Faculty of engineering and industry science, Swinburne Unibersity of Technology, Melbourne, Victoria
国际会议
2009 International Conference on Advanced Fibers and Polymer Materials(2009年先进纤维与聚合物材料国际学术会议)
上海
英文
261-263
2009-10-21（万方平台首次上网日期，不代表论文的发表时间）